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The severity of AEs had been graded on an FDA-specified scale for wholesome Grownup and adolescent volunteers.23 Vital symptoms involved systolic and diastolic arterial blood pressures, pulse, and respiratory charge. Vital symptoms had been received at screening baseline and prior to and just after Every single study drug administration in trial A. In trial B, baseline very important indications have been received after for every phase just before paroxetine administration after which you can when just after Every paroxetine and examine drug administration. Critical symptoms had been acquired in trials A and B at the end of Every single procedure phase and ahead of discharge.

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